UCF-101 | Omi/HtrA2 inhibitor | Probechem Biochemicals

Chemical Structure : UCF-101

CAS No.: 313649-08-0

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UCF-101 (UCF101, ucf-101)

货号: PC-22416Not For Human Use, Lab Use Only.

UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2880	In stock
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100 mg		Get quote

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生物&药学活性

UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases.
UCF-101 restores heart dysfunction following ischemia/reperfusion injury in vivo.
UCF-101 prevented loss of membrane integrity by inhibiting fodrin breakdown in cardiomyocytes.
UCF-101 rescues cardiomyocytes from ischemia/reperfusion injury by inhibiting XIAP degradation and Fas/Fas-ligand-induced apoptosis, thereby ameliorating ischemia/reperfusion-induced myocardial dysfunction.

物理化学性质&存储条件

分子量	495.51
分子式	C27H17N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

参考文献

1. Bhuiyan MS, et al. Eur J Pharmacol. 2007 Feb 28;557(2-3):168-77.

2. Cilenti L, et al. J Biol Chem. 2003 Mar 28;278(13):11489-94

UCF-101 (UCF101, ucf-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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UCF-101 (UCF101, ucf-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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