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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-UC495
UC495

Chemical Structure : UC495

CAS No.:

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UC495 (UC-495)

货号: PC-26283Not For Human Use, Lab Use Only.

UC495 is a specific small molecule inhibitor of deubiquitinase OTULIN, interacts with the OTULIN deubiquitinase binding pocket.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UC495 is a specific small molecule inhibitor of deubiquitinase OTULIN, interacts with the OTULIN deubiquitinase binding pocket.
UC495 selectively decreases phosphorylated tau at AT8 site in sAD2.1 iPSNs.
UC495 decreases tau levels in in human neuroblastoma cell line, SH-SY5Y.

物理化学性质&存储条件

分子量 678.77
分子式 C38H39FN6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-((R)-3-(1H-imidazol-4-yl)-1-(((S)-1-(methylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-3-(4-fluorophenyl)-2-(3-(4-hydroxyphenyl)propanamido)propanamide

参考文献

1. Tangavelou K, et al. Genom Psychiatry. 2025 Nov 29;1(6):48-58.

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