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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Ubiquitin-conjugating Enzyme (E2)-UC-764864
UC-764864

Chemical Structure : UC-764864

CAS No.: 278806-03-4

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UC-764864 (UC764864)

货号: PC-72868Not For Human Use, Lab Use Only.

UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.
UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

物理化学性质&存储条件

分子量 322.426
分子式 C19H18N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-Ethylphenyl)-3-((5-methyl-1H-benzo[d]imidazol-2-yl)thio)prop-2-en-1-one

参考文献

1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.

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