UBE2D3 inhibitor QX-6

Chemical Structure : UBE2D3 inhibitor QX-6

加入收藏

货号: PC-25849Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

UBE2D3 inhibitor QX-6 is a potent UBE2D3 (UbcH5c) inhibitor, binds to the catalytic active domain of UBE2D3 with MST KD of 12.68 nM, enhances IFN-γ-induced antigen peptide presentation in cancer cells.
QX-6 inhibited the E2-ubiquitin thioester conjugate activity of UBE2D3 in cell-free assays and inhibited TAP2 K63 linkage polyubiquitination in vitro.
QX-6 treatment enhanced and prolonged antigen presentation in IFN-γ-activated cancer cells, a response attenuated by UBE2D3.
QX-6 at doses of 10–100 mg/kg significantly inhibited tumor growth in immunocompetent subcutaneous KPC model, increased the population of tumor-infiltrating T lymphocytes in C57BL/6 mice.
QX-6 synergistically enhanced TCR-T-cell immunotherapy against PDAC, promoted the cytotoxicity of tumor-infiltrating CD8+ T cells in both CD45.2 donors and CD45.1 recipients.

物理化学性质&存储条件

分子量	458.40
分子式	C24H28BrNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3aS,9bR)-8-((2-bromobenzyl)oxy)-3-((dimethylamino)methyl)-6,9-dimethyl-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

参考文献

1. Wang S, et al. Nat Commun. 2025 Nov 28;16(1):10733.