UA49

Chemical Structure : UA49

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货号: PC-27392Not For Human Use, Lab Use Only.

UA49 is a small molecule inhibitor of plant inward-rectifying potassium channel KAT1, KAT2, promotes a decrease in the cytosolic K+ content in guard cells, conferring significant drought tolerance in Arabidopsis.

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生物&药学活性

UA49 is a small molecule inhibitor of plant voltage-dependent inward K+ channel KAT1, KAT2, promotes a decrease in the cytosolic K+ content in guard cells, conferring significant drought tolerance in Arabidopsis.
KAT1 (10 uM) inhibited inward K+ currents at the plasma membrane in whole-cell patch clamp recordings with Arabidopsis guard cell protoplasts.
KAT1 shows no directly affects Ca2+ permeable cation (ICa) channels.
KAT1 can promote stomatal closure and inhibit stomatal opening.
KAT1 induces stomatal closure and enhance drought stress tolerance, with no side effects compared with those observed with ABA.
KAT1 induce stomatal closure through a different mechanism from ABA, causes changes in the cytosolic Ca2+ concentration in guard cells via K+ inward channels.

物理化学性质&存储条件

分子量	634.52
分子式	C15H8ClF3I2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-chloro-5-(trifluoromethyl)phenyl)-3-(2,4-diiodo-6-(1H-tetrazol-5-yl)phenyl)urea

参考文献

1. Sato K, et al. Nat Commun. 2026 Jul 27;17(1):7257.

UA49

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物理化学性质&存储条件

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UA49

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