Tudociclib (INCB123667) | CDK2 inhibitor | Probechem Biochemicals

Chemical Structure : Tudociclib

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Tudociclib (INCB123667, INCB-123667)

货号: PC-27510Not For Human Use, Lab Use Only.

Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9.

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生物&药学活性

Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9.
INCB123667 inhibits phosphorylation of retinoblastoma (Rb), a CDK2/cyclin E substrate and key regulator of the G1-S transition.
INCB123667 inhibits the expression of cell cycle regulatory genes in cyclin E-overexpressed cancer cells.
INCB123667 resulted in G1 cell cycle arrest and cell senescence in ceullar assays.
INCB123667 inhibits Rb phosphorylation and resulted in dose-dependent tumor growth inhibition along with minimal body weight loss in OVCAR3 tumor xenograft model.

物理化学性质&存储条件

分子量	419.50
分子式	C18H25N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-ethoxy-N-((3R,4S)-3-methyl-1-(methylsulfonyl)piperidin-4-yl)-7-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

参考文献

1. S. Wee, et al. European Journal of Cancer. Volume 174, Supplement 1S79October 2022

2. Patent WO2021072232 A1 2021-04-15.

Tudociclib (INCB123667, INCB-123667)

生物&药学活性

物理化学性质&存储条件

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Tudociclib (INCB123667, INCB-123667)

生物&药学活性

物理化学性质&存储条件

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