Tucidinostat (Chidamide, HBI-8000, CS055)| HDAC inhibitor

Chemical Structure : Tucidinostat

CAS No.: 1616493-44-7

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Tucidinostat (Chidamide, HBI-8000, CS-055)

货号: PC-35344Not For Human Use, Lab Use Only.

Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively.
Tucidinostat (HBI-8000) shows no activity against Class IIa HDAC4/4/7/9 and HDAC6.
Tucidinostat (HBI-8000) demonstrates significant and broad spectrum in vitro and in vivo antitumor activity, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

物理化学性质&存储条件

分子量	390.418
分子式	C22H19FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide

参考文献

1. Ning ZQ, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.

2. Gong K, et al. Biochem J. 2012 May 1;443(3):735-46.

3. Dong M, et al. Cancer Chemother Pharmacol. 2012 Jun;69(6):1413-22.

4. Gao S, et al. Anticancer Agents Med Chem. 2017;17(6):802-812.

Tucidinostat (Chidamide, HBI-8000, CS-055)

生物&药学活性

物理化学性质&存储条件

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Tucidinostat (Chidamide, HBI-8000, CS-055)

生物&药学活性

物理化学性质&存储条件

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