Tps1 inhibitor 4456dh | Fungal Tps1 inhibitor | Probechem Biochemicals

Chemical Structure : Tps1 inhibitor 4456dh

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Tps1 inhibitor 4456dh (4456-dichloride hydrate)

货号: PC-24646Not For Human Use, Lab Use Only.

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生物&药学活性

Tps1 inhibitor 4456dh is a small molecule inhibitor of the fungal first enzyme in the trehalose biosynthesis pathway, trehalose-6-phosphate synthase (Tps1), demonstrates broad-spectrum inhibitory effects against multiple pathogenic fungal species, including Candida and Cryptococcus.
4456dh displays temperature-dependent fungicidal activity, phenocopying the tps1Δ fungicidal phenotype.
4456dh inhibits the biosynthesis of trehalose in fungal cells.
4456dh shows binding affinities with recombinant 6xHis-CaTps1 (C. albicans Tps1) and 6xHis-CnTps1 (C. neoformans Tps1) are 7.1 μM and 33.4 μM, respectively.
4456dh renders normally thermotolerant fungal pathogens unable to survive at elevated temperatures.

物理化学性质&存储条件

分子量	390.28
分子式	C14H17Cl2N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)-2-(pyridin-2-yl)acetamide dihydrochloride hydrate

参考文献

1. Miao Y, et al. bioRxiv [Preprint]. 2025 Mar 7:2025.03.07.642065.

Tps1 inhibitor 4456dh (4456-dichloride hydrate)

生物&药学活性

物理化学性质&存储条件

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Tps1 inhibitor 4456dh (4456-dichloride hydrate)

生物&药学活性

物理化学性质&存储条件

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