Tozorakimab | Anti-IL-33 mAb | Probechem Biochemicals

Chemical Structure : Tozorakimab

CAS No.: 2376858-66-9

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Tozorakimab (MEDI-3506, MEDI3506)

货号: PC-24499Not For Human Use, Lab Use Only.

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33 (IL-33), blocks IL-33red and IL-33ox signalling, reduces inflammation and epithelial dysfunction.

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1 mg	￥2280	In stock
5 mg	￥5580	In stock
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生物&药学活性

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33 (IL-33), blocks IL-33red and IL-33ox signalling, reduces inflammation and epithelial dysfunction.
Tozorakimab (MEDI-3506) inhibits reduced IL-33 (IL-33red) and oxidized IL-33 (IL-33ox) activities through distinct serum-stimulated 2 (ST2) and receptor for advanced glycation end products/epidermal growth factor receptor (RAGE/EGFR complex) signalling pathways.
Tozorakimab (MEDI-3506) has femtomolar affinity for IL-33red and a fast association rate (8.5 × 107 M-1 s-1), which is comparable to soluble ST2.
Tozorakimab (MEDI-3506) potently inhibits ST2-dependent inflammatory responses driven by IL-33 in primary human cells and in a murine model of lung epithelial injury.
Anti-[human IL-33], Human IgG1 lambda1, monoclonal antibody.

物理化学性质&存储条件

分子量	144660.00
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. England E, et al. Sci Rep. 2023 Jun 17;13(1):9825.

Tozorakimab (MEDI-3506, MEDI3506)

生物&药学活性

物理化学性质&存储条件

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Tozorakimab (MEDI-3506, MEDI3506)

生物&药学活性

物理化学性质&存储条件

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