Tizoxanide |CAS:173903-47-4 Probechem Biochemicals

Chemical Structure : Tizoxanide

CAS No.: 173903-47-4

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Tizoxanide

货号: PC-43149Not For Human Use, Lab Use Only.

Tizoxanide is the main metabolite of nitazoxanide, which is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent against anaerobic bacteria, protozoa, and a range of viruses.

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25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2480	In stock
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生物&药学活性

Tizoxanide is the main metabolite of nitazoxanide, which is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent against anaerobic bacteria, protozoa, and a range of viruses.

Tizoxanide shows anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively.

Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.

物理化学性质&存储条件

分子量	265.2453
分子式	C10H7N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 38 mg/mL
Chemical Name/SMILES	Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-

参考文献

1. Dubreuil L, et al. Antimicrob Agents Chemother. 1996 Oct;40(10):2266-70.

2. Gargala G, et al. J Antimicrob Chemother. 2000 Jul;46(1):57-60.

3. Adagu IS, et al. J Antimicrob Chemother. 2002 Jan;49(1):103-11.

4. Pankuch GA, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):1112-7.

Tizoxanide

生物&药学活性

物理化学性质&存储条件

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