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首页-小分子抑制剂&激动剂-Others-Other Targets-Tirasemtiv
Tirasemtiv

Chemical Structure : Tirasemtiv

CAS No.: 1005491-05-3

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Tirasemtiv (CK-2017357, CK2017357)

货号: PC-23227Not For Human Use, Lab Use Only.

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.

物理化学性质&存储条件

分子量 230.27
分子式 C12H14N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one

参考文献

1. Lutz AK, et al. Sci Transl Med. 2020 Jun 10;12(547):eaaz3267.

2. Collibee SE, et al. ACS Med Chem Lett. 2018 Feb 13;9(4):354-358.

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