Thyroid hormone receptor antagonist 1-850 | TR antagonist

Chemical Structure : Thyroid hormone receptor antagonist 1-850

CAS No.: 251310-57-3

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Thyroid hormone receptor antagonist 1-850 (TR-antagonist 1-850)

货号: PC-28093Not For Human Use, Lab Use Only.

Thyroid hormone receptor antagonist 1-850 (1-850) is a specific small molecule antagonst of thyroid hormone receptor (TR), antagonizes the effect of T3 on TR with IC50 of 1.5 uM, effectively blocks thyroid hormone-dependent gene expression.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

Thyroid hormone receptor antagonist 1-850 (1-850) is a specific small molecule antagonst of thyroid hormone receptor (TR, THR), antagonizes the effect of T3 on TR with IC50 of 1.5 uM, effectively blocks thyroid hormone-dependent gene expression.

物理化学性质&存储条件

分子量	463.42
分子式	C21H20F3N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(1-(4-nitrophenyl)piperidin-4-ylidene)acetyl)-N-(3-(trifluoromethyl)phenyl)hydrazine-1-carboxamide

参考文献

1. Schapira M, et al. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7354-9.

2. Westerholz S, et al. Neuroscience. 2010 Jun 30;168(2):573-89.

3. Navarrete-Ramírez P, et al. J Mol Endocrinol. 2014 Feb 1;52(1):1-9.

Thyroid hormone receptor antagonist 1-850 (TR-antagonist 1-850)

生物&药学活性

物理化学性质&存储条件

参考文献

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Thyroid hormone receptor antagonist 1-850 (TR-antagonist 1-850)

生物&药学活性

物理化学性质&存储条件

参考文献

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