Theliatinib |CAS:1353644-70-8 Probechem Biochemicals

Chemical Structure : Theliatinib

CAS No.: 1353644-70-8

加入收藏

Theliatinib (HMPL309, HMPL-309)

货号: PC-62121Not For Human Use, Lab Use Only.

Theliatinib (HMPL309) is a highly selective, potent, ATP-competitive inhibitor of EGFR with IC50 of 3 nM/22 nM for EGFR/EGFRT790M/L858R mutant, respectively.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Theliatinib (HMPL309) is a highly selective, potent, ATP-competitive inhibitor of EGFR with IC50 of 3 nM/22 nM for EGFR/EGFRT790M/L858R mutant, respectively.
Theliatinib (HMPL309) demonstrates 50-fold greater selectivity for EGFR compared to 72 other kinases.
Theliatinib (HMPL309) inhibits EGFR phosphorylation (IC50=7 nM) and cell survival in tumor cells
Theliatinib (HMPL309) shows in vivo activity in multiple xerographs such as A-431, Bcap-37 and Fadu; generally well tolerated in animals and orally bioactive.

物理化学性质&存储条件

分子量	442.523
分子式	C25H26N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide

参考文献

1. Ren Y, et al. Oncotarget. 2017 Apr 19;8(31):50832-50844.

Theliatinib (HMPL309, HMPL-309)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Theliatinib (HMPL309, HMPL-309)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.