Tecovirimat (ST-246) | Orthopoxvirus inhibitor | Probechem Biochemicals

Chemical Structure : Tecovirimat

CAS No.: 869572-92-9

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Tecovirimat (ST-246, ST246, Tpoxx)

货号: PC-35382Not For Human Use, Lab Use Only.

Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxviruses.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

Tecovirimat (ST-246, Tpoxx) is a potent, orally bioavailable, first-in-class inhibitor of orthopoxvirus egress with EC50 of 0.01-0.6 uM against a panel of Orthopoxviruses.
Tecovirimat (ST-246) is active against multiple orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruse.
Tecovirimat (ST-246) inhibits the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.

物理化学性质&存储条件

分子量	376.335
分子式	C19H15F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop(f)isoindol-2(1H)-yl)-benzamide

参考文献

1. Yang G, et al. J Virol. 2005 Oct;79(20):13139-49.

2. Quenelle DC, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):689-95.

3. Bailey TR, et al. J Med Chem. 2007 Apr 5;50(7):1442-4.

4. Quenelle DC, et al. Antimicrob Agents Chemother. 2007 Nov;51(11):4118-24.

Tecovirimat (ST-246, ST246, Tpoxx)

生物&药学活性

物理化学性质&存储条件

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Tecovirimat (ST-246, ST246, Tpoxx)

生物&药学活性

物理化学性质&存储条件

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