Tax-1-hDLG1 inhibitor 3 (iTax/PDZ-01)

Chemical Structure : Tax-1-hDLG1 inhibitor 3

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货号: PC-20988Not For Human Use, Lab Use Only.

Tax-1-hDLG1 inhibitor 3 (iTax/PDZ-01) is a small molecule inhibitor of Tax-1-hDLG1 interaction with EC50 of 11.5 uM, blocks HTLV-1 cell to cell transmission and viral replication.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

Tax-1-hDLG1 inhibitor 3 (iTax/PDZ-01) is a small molecule inhibitor of Tax-1-hDLG1 interaction with EC50 of 11.5 uM, blocks HTLV-1 cell to cell transmission and viral replication.
Tax-1-hDLG1 inhibitor 3 is a competitive inhibitor of the Tax-1-hDLG1 PDZ interaction, binds to both hDLG1 PDZ1 and PDZ2 domains, with affinity constants (KD) in the 14-21 uM.
Tax-1-hDLG1 inhibitor 3 (50 uM, 48 h) inhibits HTLV-1 viral replication in MT2 and C91 cells, decreases the expression of the structural protein Gag for both cell lines, does not show anti-viral effect against HIV-1.

物理化学性质&存储条件

分子量	430.39
分子式	C25H15FO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,3'-((3-fluorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

参考文献

1. Maseko SB, et al. Antiviral Res. 2023 Jul 20:105675.