Tat-beclin 1 | autophagy inducer, | Probechem Biochemicals

Chemical Structure : Tat-beclin 1

CAS No.: 1423821-88-8

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Tat-beclin 1 (Tat-BECN1, Tat-Beclin-1)

货号: PC-25236Not For Human Use, Lab Use Only.

Tat-beclin 1 (Tat-BECN1, Tat-Beclin-1) is a potent, specific inducer of autophagy that interacts with negative regulator of autophagy GAPR-1 (also called GLIPR2).

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

Tat-beclin 1 (Tat-BECN1, Tat-Beclin-1) is a potent, specific inducer of autophagy that interacts with negative regulator of autophagy GAPR-1 (also called GLIPR2).
Tat-beclin 1 binds the autophagy inhibitor GAPR-1.
Tat-beclin 1 decreases aggregates of a polyglutamine expansion protein and has anti-infective activity, decreases the intracellular survival of L. monocytogenes in primary murine bone-marrow-derived macrophages (BMDMs).
Tat-beclin 1 (0.5, 1, 2.5, and 5 μM) markedly inhibits HIV-1 replication in primary human MDMs.
Tat-beclin 1 induces autophagy and exerts antiviral activity in vivo.
Tat-Beclin 1 induces dose-dependent death that is blocked by pharmacological or genetic inhibition of autophagy, but not of apoptosis or necroptosis.

物理化学性质&存储条件

分子量	3741.10
分子式	C164H251N57O45
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr

参考文献

1. Shoji-Kawata S, et al. Nature. 2013 Feb 14;494(7436):201-6.

2. Liu Y, et al. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20364-71.

Tat-beclin 1 (Tat-BECN1, Tat-Beclin-1)

生物&药学活性

物理化学性质&存储条件

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Tat-beclin 1 (Tat-BECN1, Tat-Beclin-1)

生物&药学活性

物理化学性质&存储条件

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