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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-Taraxasterol
Taraxasterol

Chemical Structure : Taraxasterol

CAS No.: 1059-14-9

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Taraxasterol

货号: PC-27612Not For Human Use, Lab Use Only.

Taraxasterol a pentacyclic triterpene compound with anti-oxidative and anti-apoptotic properties, activates LXRα-ABCA1 signaling pathway, upregulates histidine triad nucleotide-binding protein 1 (Hint1) expression in liver cancer cells.

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10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Taraxasterol a pentacyclic triterpene compound with anti-oxidative and anti-apoptotic properties, activates LXRα-ABCA1 signaling pathway, upregulates histidine triad nucleotide-binding protein 1 (Hint1) expression in liver cancer cells.
Taraxasterol prevents cisplatin-induced cochlear hair cell loss via inducing GNAQ.
Taraxasterol dose-dependently inhibits LPS-induced TNF-α and IL-1β production and NF-κB activation in BV2 microglia cells.
Taraxasterol dose-dependently suppresses MMP-1, MMP3, MMP13, PGE2 and NO production induced by IL-1β in osteoarthritic chondrocytes.
Taraxasterol protects against OVA-induced allergic asthma in mice.
Taraxasterol significantly inhibites the growth of HCC cells both in vitro and in vivo by regulating T lymphocytes.
Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression.

物理化学性质&存储条件

分子量 426.73
分子式 C30H50O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4aR,6aR,6bR,8aR,12S,12aR,12bR,14aR,14bR)-4,4,6a,6b,8a,12,14b-Heptamethyl-11-methylenedocosahydropicen-3-ol

参考文献

1. Zhang X, et al. J Ethnopharmacol. 2012 May 7;141(1):206-11.

2. Liu B, et al. Front Pharmacol. 2018 Apr 4;9:278.

3. Piao T, et al. Eur J Pharmacol. 2015 Jun 5;756:38-42.

4. Liu J, et al. J Ethnopharmacol. 2013 Jul 30;148(3):787-93.

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