Tagtociclib hydrate | CDK2 inhibitor | Probechem Biochemicals

Chemical Structure : Tagtociclib hydrate

CAS No.: 2733575-91-0

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Tagtociclib hydrate (PF-07104091 hydrate)

货号: PC-24530Not For Human Use, Lab Use Only.

Tagtociclib hydrate (PF-07104091) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers.

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10 mg	￥2980	In stock
25 mg	￥4880	In stock
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生物&药学活性

Tagtociclib hydrate (PF-07104091) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers.
PF-07104091 displays 100-fold selectivity against CDK1, 200 to 400-fold selectivity against CDK4 and CDK6, 170-fold selectivity against CDK9, and greater than 500-fold selectivity against GSK3B.
PF-07104091 demonstrated a dose-dependent tumor growth reduction with 86 percent maximal effect in ovarian cancer model and demonstrated single-agent efficacy across multiple ovarian models.

物理化学性质&存储条件

分子量	422.49
分子式	C19H30N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate hydrate

参考文献

1. Arora M, et al. Cell. 2023 Jun 8;186(12):2628-2643.e21.

Tagtociclib hydrate (PF-07104091 hydrate)

生物&药学活性

物理化学性质&存储条件

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Tagtociclib hydrate (PF-07104091 hydrate)

生物&药学活性

物理化学性质&存储条件

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