Tacaciclib (XL102, AUR102) | CDK7 inhibitor | Probechem Biochemicals

Chemical Structure : Tacaciclib

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Tacaciclib (AUR-102, XL-102, XL102, AUR102)

货号: PC-23060Not For Human Use, Lab Use Only.

Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor.

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生物&药学活性

Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor.
Tacaciclib (XL102, AUR102) selectively targets, covalently binds to and inhibits the activity of CDK7, thereby inhibiting CDK7-mediated signaling.
Tacaciclib (XL102, AUR102) prevents phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II, thereby preventing transcription of important cancer-promoting genes.

物理化学性质&存储条件

分子量	528.65
分子式	C30H36N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(αS)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]benzeneacetamide

参考文献

1. Amita Patnaik, et al. Cancer Res (2023) 83 (5_Supplement): P4-01-35.

Tacaciclib (AUR-102, XL-102, XL102, AUR102)

生物&药学活性

物理化学性质&存储条件

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Tacaciclib (AUR-102, XL-102, XL102, AUR102)

生物&药学活性

物理化学性质&存储条件

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