TYY-31

Chemical Structure : TYY-31

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货号: PC-26587Not For Human Use, Lab Use Only.

TYY-31 is a potent, highly selective sphingosine-1-phosphate receptor 3 (S1PR3) agonist with EC50 of 1.13 pM, with minimal activity against S1PR2/3/5 (EC50 >10 uM).

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50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

TYY-31 is a potent, highly selective sphingosine-1-phosphate receptor 3 (S1PR3) agonist with EC50 of 1.13 pM, with minimal activity against S1PR2/3/5 (EC50 >10 uM).
TYY-31 triggered S1PR1 internalization in a concentration-dependent manner with EC50 of 0.73 nM, Emax =102.3%.
TYY-31 promoted ERK1/2 phosphorylation in a concentration-dependent manner.
TYY-31 effectively ameliorating dextran sulfate sodium-induced colitis in mice at a dose of 0.3 mg/kg.
TYY-31 demonstrated excellent cardiac safety characteristics in zebrafish-based assays.

物理化学性质&存储条件

分子量	487.54
分子式	C27H26FN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cis-3-((2-ethyl-4-(5-(4-(5-fluoropyrazin-2-yl)-3-methylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)amino)cyclobutane-1-carboxylic acid

参考文献

1. Ye T, et al. J Med Chem. 2026 Apr 17. doi: 10.1021/acs.jmedchem.5c03837.

TYY-31

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物理化学性质&存储条件

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TYY-31

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物理化学性质&存储条件

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