TYK2 activator 6g

Chemical Structure : TYK2 activator 6g

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货号: PC-27282Not For Human Use, Lab Use Only.

TYK2 activator 6g is a potent, selective small molecule TYK2 activator with EC50 of 0.21 uM (JH1/JH2 TYK2), maximal activation effect (Emax) of 7.8-fold.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TYK2 activator 6g is a potent, selective small molecule TYK2 activator with EC50 of 0.21 uM (JH1/JH2 TYK2), maximal activation effect (Emax) of 7.8-fold.
TYK2 activator 6g does not inhibit JAK1 or JAK2 (IC50 > 10 μM), demonstrates excellent selectivity, inhibiting only JAK3 by more than 50% at 1 uM against a broader panel of 48 kinases.

物理化学性质&存储条件

分子量	481.53
分子式	C28H24FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(phenylethynyl)phenyl)amino)-N-methylnicotinamide

参考文献

1. Matsumoto H, et al. Bioorg Med Chem Lett. 2026 Jul 7:130728.