TTZ-2 | zDHHC2 inhibitor | Probechem Biochemicals

Chemical Structure : TTZ-2

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TTZ-2 (zDHHC2 inhibitor TTZ2)

货号: PC-25635Not For Human Use, Lab Use Only.

TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 1.3 uM.

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生物&药学活性

TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 1.3 uM.
TTZ-2 inhibits zDHHC2-mediated SNAP25 S-acylation in cells with IC50 of 19 uM in HEK293T cells transfected with plasmids encoding GFP-tagged SNAP25b and HA-tagged zDHHC2.
TTZ-2 shows no effect on S-acylation of SNAP25 by zDHHC3 and zDHHC7.
TTZ-2 (25 uM) significantly inhibits PSD95-mCHERRY S-acylation by zDHHC2 and zDHHC15 in HEK293T cells.

物理化学性质&存储条件

分子量	470.53
分子式	C26H26N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-tetrazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-4-(4-phenylbutoxy)benzamide

参考文献

1. Salaun C, et al. J Biol Chem. 2022 Oct;298(10):102469.

TTZ-2 (zDHHC2 inhibitor TTZ2)

生物&药学活性

物理化学性质&存储条件

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TTZ-2 (zDHHC2 inhibitor TTZ2)

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物理化学性质&存储条件

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