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首页-小分子抑制剂&激动剂-Tyrosine Kinase-PDGFR-TSU-68
TSU-68

Chemical Structure : TSU-68

CAS No.: 252916-29-3

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TSU-68 (SU-6668;TSU68;TSU 68;SU6668;Orantinib)

货号: PC-42630Not For Human Use, Lab Use Only.

TSU-68 (Orantinib, SU6668) is a small-molecule, ATP-competitive inhibitor of angiogenic related RTKs KDR, PDGFRβ, FGFR1.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TSU-68 (Orantinib, SU6668) is a small-molecule, ATP-competitive inhibitor of angiogenic related RTKs KDR, PDGFRβ, FGFR1.
TSU-68 inhibits receptor tyrosine phosphorylation and mitogenesis after stimulation of cells by appropriate ligands.
TSU-68 significant growth inhibition of a diverse panel of human tumor xenografts after oral or i.p. administration.

物理化学性质&存储条件

分子量 310.3471
分子式 C18H18N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

参考文献

1. Laird AD, et al. Cancer Res. 2000 Aug 1;60(15):4152-60.

2. Shaheen RM, et al. Cancer Res. 2001 Feb 15;61(4):1464-8.

3. Marzola P, et al. Clin Cancer Res. 2004 Jan 15;10(2):739-50.

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