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首页-抗体和重组蛋白-Biosimilar Antibody-TSR-033
TSR-033

Chemical Structure : TSR-033

CAS No.:

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TSR-033 (Anti-human LAG3 mAb, human IgG4 (S228P)-Kappa)

货号: PC-Ab1107Not For Human Use, Lab Use Only.

TSR-033 is a high affinity humanized IgG4, κ mAb that specifically binds LAG-3 and blocks the interaction between LAG-3 and its ligand MHC Class II. TSR-033 serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. In a humanized mouse non-small cell lung carcinoma model, TSR-033 boosted the antitumor efficacy of PD-1 monotherapy, with a concomitant increase in immune activation..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TSR-033 is a high affinity humanized IgG4, κ mAb that specifically binds LAG-3 and blocks the interaction between LAG-3 and its ligand MHC Class II. TSR-033 serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. In a humanized mouse non-small cell lung carcinoma model, TSR-033 boosted the antitumor efficacy of PD-1 monotherapy, with a concomitant increase in immune activation.

物理化学性质&存储条件

分子量
分子式 Human IgG4 (S228P)-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

TSR-033; TSR033; Anti-Lymphocyte Activation Gene 3; Lag3 protein; Anti-human lymphocyte activation 3 protein; Anti-human LAG-3; Anti-human CD223

参考文献

1. 1, Ghosh S, et al. Mol Cancer Ther. 2019 Mar;18(3):632-641.  2, Sullivan MR, et al. Cell Death Dis. 2020 Nov 13;11(11):979.

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