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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-TSL-1502M
TSL-1502M

Chemical Structure : TSL-1502M

CAS No.: 2556475-01-3

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TSL-1502M (TSL1502M)

货号: PC-27717Not For Human Use, Lab Use Only.

TSL-1502M is a potent PARP1 and PARP2 inhibitor with IC50 of 0.66 nM and 0.87 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TSL-1502M is a potent PARP1 and PARP2 inhibitor with IC50 of 0.66 nM and 0.87 nM respectively.
TSL-1502M induces persistent DSBs, G2/M arrest and apoptosis in HR-deficient cells, and displays stronger effects than olaparib.
TSL-1502M selectively inhibits the proliferation of HR-deficient cancer cells.
TSL-1502M sensitizes both HR-deficient and HR-proficient cancer cells to conventional chemotherapy.
TSL-1502M is the metabolic active form of TSL-1502.

物理化学性质&存储条件

分子量 314.43
分子式 C18H26N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-methyl-1-(1-propylpyrrolidin-3-yl)-3,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-c]isoquinolin-5-one

参考文献

1. Wang L, et al. Am J Cancer Res. 2021 Apr 15;11(4):1632-1645.

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