TRβ antagonist NH-3

Chemical Structure : TRβ antagonist NH-3

CAS No.: 447415-26-1

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货号: PC-25619Not For Human Use, Lab Use Only.

TRβ antagonist NH-3 is a potent, selective antagonist of Thyroid hormone receptor beta (TRβ) with binding KD of 20 nM (hTRβ) and 93 nM (TRα1).

规格	价格	库存
1 mg	￥1480	In stock
5 mg	￥3580	In stock
10 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TRβ antagonist NH-3 is a potent, selective antagonist of Thyroid hormone receptor beta (TRβ) with binding KD of 20 nM (hTRβ) and 93 nM (TRα1).
NH-3 is TRβ-selective in both binding and inhibition of T3-induced transactivation.
NH-3 blocks 1 nM T3 induced transactivation in a dose-dependent manner with IC50 of 370 nM.
NH-3 inhibits PCa cell proliferation in vitro and reduced tumor size in PCa xenograft models in vivo.

物理化学性质&存储条件

分子量	473.53
分子式	C28H27NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-Hydroxy-3-isopropyl-5-((4-nitrophenyl)ethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid

参考文献

1. Nguyen NH, et al. J Am Chem Soc. 2005 Apr 6;127(13):4599-608.

2. Nguyen NH, et al. J Med Chem. 2002;45(15):3310–20.