TRPV2 activator AV2-1 | TRPV2 agonist | Probechem Biochemicals

Chemical Structure : TRPV2 activator AV2-1

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TRPV2 activator AV2-1 (Activator of vanilloid 2 channel 1)

货号: PC-28018Not For Human Use, Lab Use Only.

TRPV2 activator AV2-1 is a potent, selective TRPV2 activator, activates mTRPV2 (EC50=13.6 μM), hTRPV2 (EC50=51.8 μM) and rat TRPV2 (rTRPV2; EC50=36.3 μM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TRPV2 activator AV2-1 is a potent, selective TRPV2 activator, activates mTRPV2 (EC50=13.6 μM), hTRPV2 (EC50=51.8 μM) and rat TRPV2 (rTRPV2; EC50=36.3 μM).
AV2-1 shows no activity against thermoTRPV channels (TRPV1, TRPV3 and TRPV4), TRPM2 and TRPM8.
AV2-1 robustly activates TRPV2 at concentrations of 50 and 100 μM for HEKmTRPV2 and HEKhTRPV2, respectively, in fura-2-mediated single cell [Ca2+]i assays.
AV2-1 exerts low toxicity in HEKTRPV2 cells and in human peripheral blood-derived macrophages (hPBDM).
AV2-1 activates TRPV2 channels in human macrophages derived from peripheral blood.
AV2-1 induces mouse bone marrow-derived mast cells (mBMMCs) degranulation.

物理化学性质&存储条件

分子量	347.39
分子式	C17H17NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1-(2-Furylsulfonyl)-1,2,3,4-tetrahydro-4-quinolinyl]cyclopropanecarboxylic acid

参考文献

1. Leipe A, et al. Br J Pharmacol. 2026 Jul;183(13):3538-3557.

2. Leipe A, et al. Cell Calcium. 2026 Jul;136:103166.

TRPV2 activator AV2-1 (Activator of vanilloid 2 channel 1)

生物&药学活性

物理化学性质&存储条件

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TRPV2 activator AV2-1 (Activator of vanilloid 2 channel 1)

生物&药学活性

物理化学性质&存储条件

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