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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-TRPM8 antagonist Compound 496
TRPM8 antagonist Compound 496

Chemical Structure : TRPM8 antagonist Compound 496

CAS No.: 1104625-82-2

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TRPM8 antagonist Compound 496

货号: PC-28383Not For Human Use, Lab Use Only.

TRPM8 antagonist Compound 496 is a potent and selective antagonists of TRPM8, potently inhibits menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8 with IC50 of 25.8 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TRPM8 antagonist Compound 496 is a potent and selective antagonists of TRPM8, potently inhibits menthol and cold-induced increase in intracellular calcium in cells expressing rat TRPM8 with IC50 of 25.8 nM.

物理化学性质&存储条件

分子量 521.53
分子式 C24H18F3NO5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(N-(3-methylbenzo[b]thiophen-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

参考文献

1. Gavva NR, et al. Mol Pain. 2012 May 9;8:36.

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