TRPM4 inhibitor PBA

Chemical Structure : TRPM4 inhibitor PBA

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货号: PC-26527Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TRPM4 inhibitor PBA is a specific small molecule inhibitor of Ca2+-activated monovalent cation channel TRPM4 with IC50 of 339 nM using the fluorescence-based Na+-influx assay on HEK293 cells stably overexpressing hTRPM4.
TRPM4 inhibitor PBA inhibits TRPM4-mediated currents in whole-cell patch-clamp recordings from HCT116 cells with IC50 of 0.15 uM. TRPM4 inhibitor PBA inhibits both human and mouse TPRM4 but not human TRPM5.

物理化学性质&存储条件

分子量	359.76
分子式	C18H14ClNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-2-(2-(3-(prop-2-yn-1-yloxy)phenoxy)acetamido)benzoic Acid

参考文献

1. Gerber CE, et al. J Med Chem. 2026 Apr 13. doi: 10.1021/acs.jmedchem.5c02015.