TREM2 agonist S9

Chemical Structure : TREM2 agonist S9

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货号: PC-26079Not For Human Use, Lab Use Only.

TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM.

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生物&药学活性

TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM.
TREM2 agonist S9 increases SYK phosphorylation in HEK cells expressing TREM2/DAP12, but no in parental HEK cells lacking TREM2/DAP12 expression.
TREM2 agonist S9 engages TREM2 in a manner that preserves signal propagation rather than inducing biased or abortive activation.
TREM2 agonist S9 (1, 5, and 10 µM) modulates Aβ-induced microglial responses in a TREM2-dependent manner in human iPSC-derived microglia, exhibits reduction in IL-1β secretion.
TREM2 agonist S9 preserves synaptic markers in neuron–microglia co-cultures under amyloid stress, exhibits strong suppression of Aβ-induced inflammatory signaling, TREM2-dependent activity, modulation of ApoE secretion, and preservation of synaptic markers.

物理化学性质&存储条件

分子量	390.44
分子式	C23H22N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(benzofuran-3-yl)-4-methoxy-N-methyl-5-(3-methylenecyclobutane-1- carboxamido)benzamide

参考文献

1. Nada H, et al. bioRxiv [Preprint]. 2026 Jan 21:2026.01.19.700278.

TREM2 agonist S9

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TREM2 agonist S9

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