TREM2 agonist C1

Chemical Structure : TREM2 agonist C1

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货号: PC-25013Not For Human Use, Lab Use Only.

TREM2 agonist C1 is a structural analog of VG-3927 and small molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 71.36 uM in MST assays.

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生物&药学活性

TREM2 agonist C1 is a structural analog of VG-3927 and small molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 71.36 uM in MST assays.
C1 induces TREM2 activation in HEK293-hTREM2/DAP12 cells.
C1 also demonstrates a superior pharmacokinetic profile to VG-3927
C1 induced statistically significant increases in SYK phosphorylation, indicating potent activation of the TREM2–DAP12 signaling cascade.
C1 (25 uM) enhanced microglial phagocytosis by approximately 1.7 times.

物理化学性质&存储条件

分子量	449.91
分子式	C24H21ClFN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-(6-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-2H-pyran-4-yl)pyrido[3,4-b]pyrazine

参考文献

1. Shaoren Yuan, et al. bioRxiv [Preprint]. 2025 Jun 26:2025.06.22.660908.

TREM2 agonist C1

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TREM2 agonist C1

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