TREM2 agonist As48

Chemical Structure : TREM2 agonist As48

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货号: PC-25436Not For Human Use, Lab Use Only.

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50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis.
As48 binds to TREM2 with a KD of 13.8 uM in MST assays.
As48 binds to TREM1 with a KD of 97.92 uM, 7-fold weaker binding compared to its affinity for TREM2.
As48 demonstrates no significant cytotoxicity in HMC3 human microglial cells up to 100 uM.
As48 functions as a TREM2 agonist by inducing SYK phosphorylation and downstream calcium signaling in HEK293-hTREM2/DAP12 cells.
As48 (30 uM) activates TREM2 signaling in human microglial cells, enhances microglial phagocytic function.
As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activity, does not function as a direct ADAM protease inhibitor.

物理化学性质&存储条件

分子量	345.42
分子式	C20H15N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(imidazo[1,2-a]pyridin-2-yl)indolin-1-yl)(thiophen-2-yl)methanone

参考文献

1. Sungwoo Cho, et al. bioRxiv [Preprint]. 2025 Aug 28:2025.08.23.671919.