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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-TRAM-34
TRAM-34

Chemical Structure : TRAM-34

CAS No.: 289905-88-0

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TRAM-34 (TRAM34)

货号: PC-35994Not For Human Use, Lab Use Only.

TRAM-34 (TRAM34) is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1 channel) with Kd of 20 nM.

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10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TRAM-34 (TRAM34) is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1 channel) with Kd of 20 nM.
TRAM-34 displays 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels.

物理化学性质&存储条件

分子量 344.84
分子式 C22H17ClN2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

参考文献

1. Wulff H, et al. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.

2. Köhler R, et al. Circulation. 2003 Sep 2;108(9):1119-25.

3. Wulff H, et al. J Biol Chem. 2001 Aug 24;276(34):32040-5.

4. Ghanshani S, et al. J Biol Chem. 2000 Nov 24;275(47):37137-49.

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