TP003 |CAS:628690-75-5 Probechem Biochemicals

Chemical Structure : TP003

CAS No.: 628690-75-5

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TP003 (TP 003)

货号: PC-62771Not For Human Use, Lab Use Only.

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM).

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5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM).
TP003 produces a robust anxiolytic-like effect in both rodent and non-human primate behavioral models of anxiety.
TP003 also retains efficacy in a stress-induced hyperthermia model.

物理化学性质&存储条件

分子量	407.396
分子式	C23H16F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile

参考文献

1. Dias R, et al. J Neurosci. 2005 Nov 16;25(46):10682-8.

2. Fradley RL, et al. J Psychopharmacol. 2007 Jun;21(4):384-91.

TP003 (TP 003)

生物&药学活性

物理化学性质&存储条件

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TP003 (TP 003)

生物&药学活性

物理化学性质&存储条件

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