TP-238 (TP238)

Chemical Structure : TP-238

CAS No.: 2415263-04-4

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货号: PC-35848Not For Human Use, Lab Use Only.

TP-238 (TP238) is a potent, selective CECR2/BPTF bromodomains chemical probe inhibitor with IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay, KD of 10 nM for CECR2 and 120 nM for BPTF in ITC assays.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TP-238 (TP238) is a potent, selective CECR2/BPTF bromodomains chemical probe inhibitor with IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay, KD of 10 nM for CECR2 and 120 nM for BPTF in ITC assays.
TP-238 has been profiled against the panel of 338 kinases and showed no activity at 1 uM, the closest off-target bromodomain inhibition is BRD9 with IC50 of 1.4 uM.

物理化学性质&存储条件

分子量	458.581
分子式	C22H30N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1H-pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine

参考文献

1. Michael A Clegg, et al. ChemMedChem. 2019 Feb 19;14(4):362-385.

TP-238 (TP238)

生物&药学活性

物理化学性质&存储条件

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TP-238 (TP238)

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物理化学性质&存储条件

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