TNIK inhibitor OBD9 | TNIK inhibitor | Probechem Biochemicals

Chemical Structure : TNIK inhibitor OBD9

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TNIK inhibitor OBD9 (OBD9)

货号: PC-49469Not For Human Use, Lab Use Only.

OBD9 is a small molecule TNIK inhibitor that blocks Wnt/beta-catenin signaling at the final step of transcriptional activation, suppresses colorectal cancer growth by interfering with the Wnt signaling pathway.

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生物&药学活性

OBD9 is a small molecule TNIK inhibitor that blocks Wnt/beta-catenin signaling at the final step of transcriptional activation, suppresses colorectal cancer growth by interfering with the Wnt signaling pathway.
OBD9 induces autophagic degradation of TNIK (traf2 and Nck-interacting kinase), which promotes T-cell factor-4 (TCF4)/beta-catenin–mediated gene expression.

物理化学性质&存储条件

分子量	380.40
分子式	C20H20N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (5-(4-(methyl(oxetan-3-yl)amino)benzoyl)-1H-benzo[d]imidazol-2-yl)carbamate

参考文献

1. Zhou K, et al. Mol Cancer Ther. 2022 Oct 27:MCT-21-0801.
2. Jae Eun Cheong, et al. Eur J Med Chem. 2018 Jan 20:144:372-385.

TNIK inhibitor OBD9 (OBD9)

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物理化学性质&存储条件

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TNIK inhibitor OBD9 (OBD9)

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物理化学性质&存储条件

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