欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-TNG-6132
TNG-6132

Chemical Structure : TNG-6132

CAS No.: 2821749-57-7

加入收藏

TNG-6132 (TNG6132)

货号: PC-24549Not For Human Use, Lab Use Only.

TNG-6132 is a potent, selective, reversible, allosteric and orally bioavailable USP1 inhibitor with pIC50 of 7.9 (USP1-UAF1 complex), and pIC50 of 7.6 in cellular viability assay with MDA-MB-436 cells.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TNG-6132 is a potent, selective, reversible, allosteric and orally bioavailable USP1 inhibitor with pIC50 of 7.9 (USP1-UAF1 complex), and pIC50 of 7.6 in cellular viability assay with MDA-MB-436 cells.
TNG-6132 interacts non-covalently with the complex by binding to a cryptic allosteric pocket in USP1.
TNG-6132 (10, 30 and 100 mg/kg) resulted in a dose-proportional plasma exposure and dose-dependent increase in the pharmacodynamic marker ub-PCNA as measured in harvested tumor samples from MDA-MB-436 cell-derived murine xenograft model.
TNG-6132 (100 mg/kg, 200 mg/kg) reduced tumor volume in PARP inhibitor-resistant BRCA1-mutated patient-derived xenograft (PDX) murine model of ovarian cancer.

物理化学性质&存储条件

分子量 505.51
分子式 C26H22F3N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-7-(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine

参考文献

1. Throner S, et al. Bioorg Med Chem Lett. 2025 Apr 30:130262.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: