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首页-小分子抑制剂&激动剂-Others-Other Targets-TMQ0153
TMQ0153

Chemical Structure : TMQ0153

CAS No.: 2246945-77-5

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TMQ0153 (TMQ153, TMQ-0153)

货号: PC-24387Not For Human Use, Lab Use Only.

TMQ0153 (TMQ153) is a tetrahydrobenzimidazole derivative with cytotoxic potential against hematopoietic cancer cell lines, targets mitochondrial dynamics by inhibiting mitochondrial fusion protein optic atrophy 1 (OPA1), inducing metabolic reprogramming, and triggering apoptosis in AML cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TMQ0153 (TMQ153) is a tetrahydrobenzimidazole derivative with cytotoxic potential against hematopoietic cancer cell lines, targets mitochondrial dynamics by inhibiting mitochondrial fusion protein optic atrophy 1 (OPA1), inducing metabolic reprogramming, and triggering apoptosis in AML cells.
TMQ0153 inhibits cell viability, proliferation and colony formation capacity of drug-sensitive and -resistant cancer cells.
TMQ0153 triggers a concentration-dependent induction of caspase-dependent and independent non-apoptotic cell death in K562 cells.
TMQ0153 activates necrostatin-1 sensitive necroptotic cell death.
TMQ0153 stimulates autophagy prior to necroptosis.
TMQ0153 depolarizes mitochondrial membrane potential and triggers necroptotic cell death through ROS formation.
TMQ0153 treatment significantly reduced OPA1 and mitofusin (MFN)2 protein levels and disrupted the mitochondrial morphology and function in AML cells.
TMQ0153 treatment reduces tumor volume and weight in MV4-11 xenografts in vivo.

物理化学性质&存储条件

分子量 276.72
分子式 C14H13ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5H-Benzimidazol-5-one, 3-(4-chlorophenyl)-3,3a,4,7a-tetrahydro-7a-hydroxy-2-methyl-, (3aR,7aR)-

参考文献

1. Song S, et al. Cell Death Dis. 2020 Feb 7;11(2):109.

2. Park SJ, et al. J Exp Clin Cancer Res. 2025 Apr 7;44(1):114.

3. Tran MQ, et al. Eur. J. Org. Chem. 2018;2018:5878–5884.

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