TMBIM6 inhibitor BIA

Chemical Structure : TMBIM6 inhibitor BIA

CAS No.: 134271-74-2

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货号: PC-24226Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

TMBIM6 inhibitor BIA is a specific inhibitor of TMBIM6 (BAX inhibitor-1, BI-1), prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, also suppresses ER release of Ca2+ from TMBIM6, has broad anticancer activities.
BIA decreases the binding between TMBIM6 and mTORC2 inhibits proliferation and cell viability of MCF7 and MDA-MB-231 cells highly expressed TMBIM6. BIA reduced cell proliferation by inducing the dissociation of TMBIM6 from mTORC2 and ribosome, result in cell death.
BIA suppresses ER release of Ca2+ from TMBIM6.
BIA decreases cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells, not TMBIM6 KO HT1080 cells.
BIA (1 mg/kg BIA, vehicle (0.1% DMSO with saline), 5 days per week during 25 days) markedly impaired cell-driven tumor growth in HT1080 and MDA-MB-231 xenograft mice.
TMBIM6, a member of the transmembrane BI-1 motif-containing family of proteins, is overexpressed in many cancer types.

物理化学性质&存储条件

分子量	268.27
分子式	C15H12N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(2-aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one

参考文献

1. Kim HK, et al. Nat Commun. 2020 Aug 11;11(1):4012.