TMBIM6 antagonist BIA | Bax inhibitor-1/TMBIM6 antagonist

Chemical Structure : TMBIM6 antagonist BIA

CAS No.: 123134-61-2

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TMBIM6 antagonist BIA (Bax inhibitor-1 antagonist, BIA)

货号: PC-28256Not For Human Use, Lab Use Only.

TMBIM6 antagonist BIA (Bax inhibitor-1 antagonist, TMBIM6 antagonist-1) is a specific small molecule TMBIM6 (Bax inhibitor-1, BI-1) antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, also regulates TMBIM6-leaky Ca2+.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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TMBIM6 antagonist BIA (Bax inhibitor-1 antagonist, TMBIM6 antagonist-1) is a specific small molecule TMBIM6 (Bax inhibitor-1, BI-1) antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, also regulates TMBIM6-leaky Ca2+.
BIA inhibits proliferation and cell viability of MCF7 and MDA-MB-231 cells highly expressed TMBIM6 with IC50 of 1.7-2.6 uM.
BIA reduces cell proliferation by inducing the dissociation of TMBIM6 from mTORC2 and ribosome, result in cell death.
BIA suppresses ER release of Ca2+ from TMBIM6. decreased cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells, but not TMBIM6 KO HT1080 cells.
BIA ( 1 mg/kg, vehicle 0.1% DMSO with saline) markedly impaired cell-driven tumor growth of injected HT1080 and MDA-MB-231 cells into immunocompromised mice.
BIA significantly attenuated inflammatory cell infiltration, goblet cell hyperplasia, airway remodelling and Th2-associated cytokine expression in the lungs of A. fumigatus-challenged mice.
Transmembrane B cell lymphoma 2-associated X protein (BAX) inhibitor motif-containing (TMBIM)6, an inhibitor of ER stress.
TMBIM6 is a Ca2+ channel-like protein that lowers the steady-state [Ca2+]ER, which is expressed in the endoplasmic reticulum (ER) membrane surface.
TMBIM6 is overexpressed in many cancer types.

物理化学性质&存储条件

分子量	268.27
分子式	C15H12N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one

参考文献

1. Kim HK, et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun. 2020 Aug 11;11(1):4012.

2. Yu YJ, et al. Br J Pharmacol. 2026 Oct;183(19):5975-5991.

TMBIM6 antagonist BIA (Bax inhibitor-1 antagonist, BIA)

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TMBIM6 antagonist BIA (Bax inhibitor-1 antagonist, BIA)

生物&药学活性

物理化学性质&存储条件

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