TLX agonist 4

Chemical Structure : TLX agonist 4

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货号: PC-27593Not For Human Use, Lab Use Only.

TLX agonist 4 (Compound 35) is highly potent and selective activator of transcription factor tailless (TLX, NR2E1) with pEC50 of 8.0.

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生物&药学活性

TLX agonist 4 (Compound 35) is highly potent and selective activator of transcription factor tailless (TLX, NR2E1) with pEC50 of 8.0.
TLX agonist 2 demonstrates upregulation of genes associated with ATP production, lysosomal function, and vesicular transport.
TLX agonist 2 induces mitochondrial quality control-associated PTEN-induced kinase 1 (PINK1), downregulates the amyloidogenic β-secretase (BACE).
TLX agonist 2 shows anti-neurodegenerative effects.

物理化学性质&存储条件

分子量	445.46
分子式	C22H18F3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-(trifluoromethyl)phenyl)-1-phenylmethanesulfonamide

参考文献

1. Hank EC, et al. J Med Chem. 2026 Jun 25;69(12):14704-14721.

TLX agonist 4

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物理化学性质&存储条件

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TLX agonist 4

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