TLR7/8/9 triple antagonist 41

Chemical Structure : TLR7/8/9 triple antagonist 41

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货号: PC-27774Not For Human Use, Lab Use Only.

TLR7/8/9 triple antagonist 41 is a potent, selective triple antagonist of TLR7/8/9 with IC50 of 8/6/72 nM for hTLR7/8/9 respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TLR7/8/9 triple antagonist 41 is a potent, selective triple antagonist of TLR7/8/9 with IC50 of 8/6/72 nM for hTLR7/8/9 respectively.
TLR7/8/9 triple antagonist 41 demonstrated robust dose-dependent inhibition of TLR7 and TLR9 pathways in mouse challenging models.

物理化学性质&存储条件

分子量	483.62
分子式	C28H33N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((2R,6S)-2-methyl-6-((4-(5,6,7,8-tetrahydro-2,6-naphthyridin-3-yl)piperazin-1-yl)methyl)morpholino)quinoline-8-carbonitrile

参考文献

1. Zhang Z, et al. J Med Chem. 2026 Aug 13;69(15):18665-18691.