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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-TLR4-IN-C34
TLR4-IN-C34

Chemical Structure : TLR4-IN-C34

CAS No.: 40592-88-9

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TLR4-IN-C34

货号: PC-26584Not For Human Use, Lab Use Only.

TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TLR4-IN-C34 is a potent TLR4 antagonist, inhibits LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cells, inhibits TLR4 in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

物理化学性质&存储条件

分子量 389.40
分子式 C17H27NO9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S,4R,5R,6S)-5-Acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate

参考文献

1. Wipf P, et al. Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

2. Neal MD, et al. PLoS One. 2013 Jun 12;8(6):e65779.

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