TJ-M11

Chemical Structure : TJ-M11

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货号: PC-24521Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4.
TJ-M11 blocks the interactions of YAP with TAF4 and MED15 in cells through Co-immunoprecipitation.
TJ-M11 disrupts the transcription of YAP target genes, including the immunosuppressive genes CSF1, ITGB2, and IL33.
TJ-M11 exhibits biological activity against cancer cell growth, inhibits primary patient-derived lung adenocarcinoma (LUAD) cells (LUAD1, IC50=6.77 uM).
TJ-M11 treatment significantly suppressed the tumor size, reverses adaptive resistance of anti-PD-1 inhibitor in TDCL tumor-bearing C57BL/6 mice.

物理化学性质&存储条件

分子量	2204.79
分子式	C112H174N26O20
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: Phe-Leu-Thr-Trp-Leu-Pro-Lys-Lys-Lys-Arg-Lys-Val-Phe-Leu-Thr-Trp-Leu

参考文献

1. Man Yu, et al. Nat Commun. 2025 Apr 24;16(1):3855.

TJ-M11

生物&药学活性

物理化学性质&存储条件

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TJ-M11

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物理化学性质&存储条件

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