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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Focal Adhesion Kinase (FAK)-THY-10A62
THY-10A62

Chemical Structure : THY-10A62

CAS No.: 2211192-15-1

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THY-10A62 (Compound 16c)

货号: PC-25557Not For Human Use, Lab Use Only.

THY-10A62 is a potent small molecule inhibitor of Focal adhesion kinase (FAK) with IC50 of 12 nM, has IC50 of 2.39 μM and 10.07 μM against the liver cancer cell lines YY8103 and SMMC7721, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

THY-10A62 is a potent small molecule inhibitor of Focal adhesion kinase (FAK) with IC50 of 12 nM, has IC50 of 2.39 μM and 10.07 μM against the liver cancer cell lines YY8103 and SMMC7721, respectively.
THY-10A62 binds to ATP-binding site of FAK.
THY-10A62 (10 and 30 mg/kg, i.p.) exhibits tumor growth inhibition in nude mice bearing SMMC7721 tumors.
THY-10A62 demonstrates in vivo antitumor activity against HCC.

物理化学性质&存储条件

分子量 447.47
分子式 C23H22FN7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((2-((3-(Acetamidomethyl)phenyl)amino)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

参考文献

1. Hanyi Tan, et al. Eur J Med Chem. 2021 Nov 5:223:113670.

2. Wanqiu Huang, et al. Front Oncol. 2025 Sep 1:15:1498005.

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