TH588 (TH-588)

Chemical Structure : TH588

CAS No.: 1609960-31-7

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货号: PC-43226Not For Human Use, Lab Use Only.

TH588 (TH-588) is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

TH588 (TH-588) is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.
TH588 shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH588 causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

物理化学性质&存储条件

分子量	295.1672
分子式	C13H12Cl2N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 16 mg/mL
Chemical Name/SMILES	2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-

参考文献

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.

3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.

TH588 (TH-588)

生物&药学活性

物理化学性质&存储条件

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TH588 (TH-588)

生物&药学活性

物理化学性质&存储条件

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