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首页-抗体和重组蛋白-Biosimilar Antibody-TGN1412
TGN1412

Chemical Structure : TGN1412

CAS No.:

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TGN1412 (Anti-human CD28 mAb, human IgG4P-Kappa)

货号: PC-Ab1030Not For Human Use, Lab Use Only.

TGN1412 is a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. TGN1412 binds to the laterally exposed C′D loop of CD28 and demonstrated its therapeutic potential for use in autoimmune disease, led to a massive and uncontrolled release of proinflammatory cytokines (cytokine storm) during clinical phase I trials..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TGN1412 is a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells. TGN1412 binds to the laterally exposed C′D loop of CD28 and demonstrated its therapeutic potential for use in autoimmune disease, led to a massive and uncontrolled release of proinflammatory cytokines (cytokine storm) during clinical phase I trials.

物理化学性质&存储条件

分子量
分子式 Human IgG4P-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

TGN1412; TGN 1412; TGN-1412; TP44; T-cell-specific surface glycoprotein CD28

参考文献

1. 1, Suntharalingam G, et al. N Engl J Med. 2006 Sep 7;355(10):1018-28. 2, Dayan CM, et al. Clin Exp Immunol. 2008 Feb;151(2):231-4. 3, Eastwood D, et al. Br J Pharmacol. 2010 Oct;161(3):512-26. 4, Panoskaltsis N, et al. Cancer Immunol Immunother. 2021 Apr;70(4):1127-1142.

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