TG2 inhibitor 1-155

Chemical Structure : TG2 inhibitor 1-155

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货号: PC-24404Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TG2 inhibitor 1-155 (TG2 inhibitor 3h) is a potent, selective small molecule Transglutaminase 2 (TG2, TGase2, TGM2) inhibitor with IC50 of 6.1 nM, >1000-fold selective over TG1, TG3, TG6, and Factor XIIIa (FXIIIa).
1-155 significantly inhibited collagen deposition in the lungs in the bleomycin-challenged mice. causes a significant reduction in a key myofibroblast marker α smooth muscle actin and TG2.
1-155 treatment (60 mg/kg twice daily via oral delivery) significantly improved several key lung function parameters, such as cord compliance, vital capacity, and dynamic compliance.

物理化学性质&存储条件

分子量	430.52
分子式	C21H26N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

参考文献

1. Wang Z, et al. Cells. 2025 Mar 26;14(7):497.

2. Eduard Badarau, et al. Chem Biol. 2015 Oct 22;22(10):1347-61.