TED-655 | TEAD-YAP1 inhibitor | Probechem Biochemicals

Chemical Structure : TED-655

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TED-655 (TED655)

货号: PC-26510Not For Human Use, Lab Use Only.

TED-655 is a small-molecule covalent inhibitor of TEAD-YAP1 transcription factor, reduces TEAD and YAP1 protein levels.

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生物&药学活性

TED-655 is a small-molecule covalent inhibitor of TEAD-YAP1 transcription factor, reduces TEAD and YAP1 protein levels.
TED-655 binds to the TEAD lipid pocket and form a covalent bond with a conserved cysteine.
TED-655 inhibits transcriptional activity of all four TEADs.
TED-655 (10 uM) shows a subtle but concentration-dependent reduction of TEAD and YAP1 protein levels in MDA-MB-231, MPNST 90-8, and SaOS-LM7 cells.
TED-655 shows no effect on TEAD1 or YAP1 mRNA levels, suggesting that reduction in protein levels of TEAD and YAP1 is likely post-translational.
TED-655 inhibits cancer cell proliferation with IC50 in the single-digit micromolar range for NCI-H226.

物理化学性质&存储条件

分子量	332.33
分子式	C18H15F3N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((4-(trifluoromethyl)phenyl)amino)isoindolin-2-yl)prop-2-en-1-one

参考文献

1. Yeh, I. J.; Bum-Erdene, K.; Ghozayel, M. K.; Gonzalez-Gutierrez, G.; Meroueh, S. O. Small-Molecule Covalent Stabilization and Inhibition of the TEAD.YAP1 Transcription Factor in Cancer Cells. ACS Chem. Biol. 2025, 20, 2142– 2158

TED-655 (TED655)

生物&药学活性

物理化学性质&存储条件

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TED-655 (TED655)

生物&药学活性

物理化学性质&存储条件

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