TDRL-505 | RPA inhibitor | Probechem Biochemicals

Chemical Structure : TDRL-505

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TDRL-505 (TDRL505)

货号: PC-25661Not For Human Use, Lab Use Only.

TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA.

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生物&药学活性

TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA.
TDRL-505 decreases cell viability and nuclear RPA staining without induction of apoptosis and degradation of RPA.
TDRL-505 affects cell cycle progression and DNA replication.
TDRL-505 acts synergistically with both cisplatin and etoposide in H460 cells.
TDRL-505 inhibits RPA-DNA interactions in vitro, blocks cell entry into S-phase and results in a cytotoxic/cytostatic response.

物理化学性质&存储条件

分子量	530.80
分子式	C24H21BrClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-bromophenyl)-5-(2-chloro-7-ethoxyquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid

参考文献

1. Mishra AK, et al. Biochem Pharmacol. 2015 Jan 1;93(1):25-33.

2. Sarah C Shuck, et al. Cancer Res. 2010 Apr 15;70(8):3189-98.

TDRL-505 (TDRL505)

生物&药学活性

物理化学性质&存储条件

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TDRL-505 (TDRL505)

生物&药学活性

物理化学性质&存储条件

参考文献

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